Stryker became known in the adult film industry for his all-American good looks, penchant for dirty talk, and his large penis. His penis is billed at 10 inches in length.

He is primarily famous as a performer in gay films, although for a number of years he strenuously asserted that he was not even bisexual in his personal life. He later admitted to being bisexual, describing his sexuality as “universal.”

He has also tried his hand at “legitimate” acting, notably starring in a 1989 Italian-produced horror movie called After Death, in which he was credited as Chuck Peyton.

Stryker has one son, who he has raised independently (after a lengthy custody battle) since the child was one year old. In September 2004, his son, then 14 years old, was the victim of a hate crime where he was surrounded by nine kids, beaten, his nose broken, and his face stabbed at Ulysses S. Grant High School in Van Nuys, California. Jeff was interviewed by TV reporters and stated that he believed that the attack was racially motivated (Jeff Stryker is of Armenian descent). Both Jeff and his son were interviewed by NBC news in Los Angeles about the incident.